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Updated: Jul 2, 2026
12:37
Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
Published on: September 11, 2012
Colonic adenoma with squamous metaplasia
1Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, Massachusetts 01199, USA. Liron.pantanowitz@bhs.org
International Journal of Surgical Pathology
|August 15, 2008
Summary
Squamous metaplasia in colon adenomas is rare, mostly affecting elderly men. This study details a case in the cecum, suggesting squamous differentiation may precede colorectal squamous neoplasia.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Squamous metaplasia in colon adenomas is a rare event, with an incidence of 0.4%, predominantly observed in elderly males.
- Adenomas represent benign neoplastic polyps in the colon, which can progress to adenocarcinoma.
Observation:
- This report describes a rare case of squamous metaplasia within a tubulovillous adenoma of the cecum.
- The adenoma was incidentally found to be associated with adenocarcinoma.
Findings:
- Immunohistochemical analysis revealed squamous metaplasia was immunoreactive for beta-catenin.
- The metaplasia was negative for cytokeratin 20, CDX2, p63, estrogen receptor, progesterone receptor, p16, and human papilloma virus.
Implications:
- Squamous differentiation within colon adenomas may represent a precursor lesion for the development of squamous neoplasia in the colorectum.
- Further research is warranted to understand the mechanisms and clinical significance of this rare phenomenon.
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