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Updated: Jul 2, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism
09:31

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Volume-guarantee ventilation: pressure may decrease during obstructed flow.

K I Wheeler1, C J Morley, C O F Kamlin

  • 1Neonatal Services, Royal Women's Hospital, Cnr Grattan Street & Flemington Road, Parkville, VIC 3052, Australia. kevin.wheeler@thewomens.org.au

Archives of Disease in Childhood. Fetal and Neonatal Edition
|August 15, 2008
PubMed
Summary
This summary is machine-generated.

During complete endotracheal tube obstruction, the Dräger Babylog 8000+ ventilator may reduce positive inspiratory pressure (PIP) to a level between maximum inflating pressure and positive end expiratory pressure (PEEP), even if the set tidal volume is not met. An external monitor may also freeze.

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Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Last Updated: Jul 2, 2026

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Published on: February 14, 2022

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
10:02

Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow

Published on: April 29, 2011

Area of Science:

  • Medical Devices
  • Respiratory Care
  • Mechanical Ventilation

Background:

  • Unexpected observations during Dräger Babylog 8000+ ventilation in volume-guarantee mode.
  • Complete endotracheal tube obstruction led to reduced positive inspiratory pressure (PIP).
  • Real-time waveforms on an external monitor ceased during tube-obstructed alarms.

Purpose of the Study:

  • Investigate unexpected Dräger Babylog 8000+ ventilation behaviors.
  • Analyze positive inspiratory pressure (PIP) changes during endotracheal tube obstruction.
  • Examine external waveform monitor performance during ventilation alarms.

Main Methods:

  • Utilized a Dräger test lung connected to a Dräger Babylog 8000+ ventilator.
  • Induced partial and complete endotracheal tube obstruction.
  • Recorded ventilator digital output at 125 Hz.

Main Results:

  • Complete endotracheal tube obstruction resulted in a constant PIP midway between maximum inflating pressure and PEEP.
  • Partial obstruction did not yield the same PIP reduction.
  • The external waveform monitor display froze during complete obstruction.

Conclusions:

  • The Dräger Babylog 8000+ ventilator adjusts PIP to a midpoint between maximum and PEEP during complete endotracheal tube obstruction.
  • This PIP reduction occurs irrespective of achieving the set expired tidal volume.
  • Further research is required to assess the clinical implications of this reduced PIP.