Related Experiment Video
Updated: Jul 2, 2026

10:28
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
Coactivators and corepressors: what's in a name?
Molecular Endocrinology (Baltimore, Md.)
|August 15, 2008
Summary
Nuclear receptor coregulators are essential for nuclear receptor function. This review addresses the complex nomenclature of these molecules, offering guidelines for clear identification in research.
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- Nuclear receptors are crucial transcription factors regulating gene expression.
- Nuclear receptor coregulators (coactivators and corepressors) modulate receptor activity.
- The field has rapidly expanded since the mid-1990s, leading to significant research.
Discussion:
- The nomenclature for nuclear receptor coregulators is complex and often redundant.
- This ambiguity can hinder interdisciplinary understanding and research collaboration.
- Examples of specific coregulators are discussed to illustrate nomenclature challenges.
Key Insights:
- A unified and clear nomenclature is needed for nuclear receptor coregulators.
- Guidelines are proposed to aid in the consistent identification of these molecules.
- Standardization will facilitate broader research and application.
Outlook:
- Improved nomenclature will enhance the study of nuclear receptor pathways.
- Clearer identification supports therapeutic target discovery.
- Facilitates integration of coregulator research into diverse biological disciplines.
More Related Videos
Related Concept Videos
Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Co-activators and Co-repressors
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
Prokaryotic Transcriptional Activators and Repressors
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
Prokaryotic Transcriptional Activators and Repressors
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
Eukaryotic Transcription Activators
Transcription activators are proteins that promote the transcription of genes from DNA to RNA. In most cases, these proteins contain two separate domains ‒ a domain that binds to DNA and a domain for activating transcription; however, in some cases, a single domain is responsible for both binding and activation of transcription, as seen in the glucocorticoid receptor and MyoD.
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
The binding domains are capable of recognizing and interacting with regulatory sequences on the DNA. These domains are...
Eukaryotic Transcription Inhibitors
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...
Eukaryotic transcription inhibitors usually contain two distinct domains, a DNA...

