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Updated: Jul 2, 2026

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
Published on: May 5, 2023
Targeting transcription factors for therapeutic benefit
Paul Brennan1, Rossen Donev, Saman Hewamana
1Medical Biochemistry & Immunology, School of Medicine, Cardiff University, Heath Park, Cardiff, UK. BrennanP@cardiff.ac.uk
Abstract:
Transcription factors are a large class of biological molecules that are important for health and disease. Despite that there are challenges to targeting them therapeutically and most approaches alter their activity indirectly. Research at the chemical biology interface has led to the development of new ways of targeting transcription factors including blocking transcription factor dimerisation, targeting specific DNA sequences and DNA decoys. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of cancer.
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