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Published on: April 4, 2018
A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer
Hua Yuan1,2,3, Hongliang Liu2,3, Zhensheng Liu2,3
1Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, China.
Researchers identified a novel genetic risk factor, rs114020893, in the long non-coding RNA NEXN-AS1, which may increase susceptibility to lung cancer. This finding contributes to understanding lung cancer
Area of Science:
- Genetics
- Molecular Biology
- Oncology
Background:
- Lung cancer development is complex, with long non-coding RNAs (lncRNAs) emerging as key factors in carcinogenesis.
- Genetic variations, specifically single nucleotide polymorphisms (SNPs), within lncRNAs may influence lung cancer risk.
Purpose of the Study:
- To conduct a large-scale meta-analysis of genome-wide association studies (GWAS) to identify novel genetic risk factors for lung cancer associated with lncRNAs.
- To validate significant findings in independent datasets and investigate the potential functional impact of identified SNPs.
Main Methods:
- A meta-analysis of six GWAS datasets (690,564 SNPs in 15,531 lncRNAs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium was performed.
- Novel significant SNPs (P < 1×10⁻⁷) were validated in two independent GWAS datasets.
- A final meta-analysis of eight GWAS datasets (17,153 cases, 239,337 controls) was conducted, followed by in silico analysis of the top SNP.
Main Results:
- A novel risk SNP, rs114020893, located in the NEXN-AS1 lncRNA region at 1p31.1, was identified with statistical significance (OR=1.17, P=8.31×10⁻⁹).
- This SNP remained significant after meta-analysis of all eight GWAS datasets.
- In silico analysis suggested that rs114020893 could alter the secondary structure of the NEXN-AS1 lncRNA.
Conclusions:
- The SNP rs114020893 in the lncRNA NEXN-AS1 region is a potential novel risk factor contributing to lung cancer susceptibility.
- These findings highlight the role of lncRNAs in lung carcinogenesis and provide a new target for genetic research in lung cancer.
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