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Updated: Jul 2, 2026

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

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Does zero balance ultrafiltration decrease the incidence of post-cardiopulmonary bypass atrial fibrillation?

Mark T Lucas¹, John Limoli, Joseph Schlut

¹Department of Surgery, Centura St. Anthony Central Hospital, Denver, Colorado, USA. mlucas56@hotmail.com

The Journal of Extra-Corporeal Technology

|August 19, 2008

Summary

This summary is machine-generated.

Postoperative atrial fibrillation (Afib) is common after cardiac surgery. This study found that while zero balance ultrafiltration (ZBUF) did not reduce Afib incidence, older age and female gender significantly increase Afib risk.

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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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Published on: February 28, 2012

Area of Science:

Cardiology
Cardiac Surgery
Critical Care Medicine

Background:

Postoperative atrial fibrillation (Afib) is a frequent complication following cardiac surgery, increasing risks of stroke, heart failure, and prolonged hospitalization.
Cardiac surgery with cardiopulmonary bypass (CPB) triggers a systemic inflammatory response syndrome (SIRS), contributing to arrhythmias.
Zero balance ultrafiltration (ZBUF) is hypothesized to mitigate SIRS by removing inflammatory mediators.

Purpose of the Study:

To investigate if zero balance ultrafiltration (ZBUF) reduces the incidence of postoperative atrial fibrillation (Afib) after cardiopulmonary bypass (CPB).

Main Methods:

A retrospective analysis of consecutive primary coronary artery bypass patients who underwent CPB between January 2004 and June 2006.
Data collected included patient demographics, Afib occurrence, ZBUF use, blood product administration, surgical times, comorbidities, and postoperative outcomes.
Univariate analysis was performed to identify factors associated with Afib, with a p-value threshold of .05.

Main Results:

New onset Afib occurred in 27% of patients.
Older age (odds ratio 1.078 per unit increase) and female gender (odds ratio 2.629) were significantly associated with an increased risk of Afib.
The study did not statistically prove the hypothesis that ZBUF reduces Afib incidence.

Conclusions:

Older age and female gender are significant risk factors for developing postoperative atrial fibrillation after cardiac surgery.
Further research is needed to confirm the efficacy of ZBUF in preventing Afib or to explore other preventative strategies.