Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

Is D-dimer helpful in evaluating stroke patients? A systematic review.

E Haapaniemi¹, T Tatlisumak

¹Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. elena.haapaniemi@hus.fi

Acta Neurologica Scandinavica

|August 19, 2008

Summary

D-dimer (DD) levels increase in stroke patients but are not reliable for diagnosis or predicting outcomes. Clinical evaluation remains superior for stroke assessment and prognosis.

Related Concept Videos

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Haptoglobin genotype and its relation to asymptomatic cerebral small-vessel disease in type 1 diabetes.

Acta diabetologica·2023

Same author

Outcomes after reperfusion therapies in patients with ACA stroke: A multicenter cohort study from the EVATRISP collaboration.

Journal of the neurological sciences·2021

Same author

Early vs. late enoxaparin for the prevention of venous thromboembolism in patients with ICH: A double blind placebo controlled multicenter study.

Clinical neurology and neurosurgery·2021

Same author

Correction to: Features of intracranial hemorrhage in cerebral venous thrombosis.

Journal of neurology·2020

Same author

Recurrent versus first cervical artery dissection - a retrospective study of clinical and vascular characteristics.

European journal of neurology·2020

Same author

Features of intracranial hemorrhage in cerebral venous thrombosis.

Journal of neurology·2020

Area of Science:

Neurology
Hematology
Biochemistry

Background:

D-dimer (DD) is a fibrin degradation product elevated in thrombotic conditions.
There is a need for simple, reliable tests to aid in stroke diagnosis and prognosis.
Previous research explored the utility of DD measurements in stroke management.

Purpose of the Study:

To systematically review current evidence on plasma DD levels in various stroke types.
To assess the diagnostic and prognostic value of DD in stroke patients.
To determine if DD testing can replace clinical or radiological evaluations.

Main Methods:

Systematic literature review of studies indexed in MEDLINE.
Keywords included 'cerebral venous thrombosis', 'D-dimer', 'stroke', 'prognosis', etc.

Related Experiment Videos

Last Updated: Jul 2, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

Focused on studies in English concerning ischemic stroke, hemorrhagic stroke, and cerebral venous thrombosis.

Main Results:

Numerous studies indicate acutely increased plasma DD levels in patients with various strokes.
Plasma DD levels lack sufficient sensitivity and specificity for stroke diagnostics.
Clinical evaluation is superior to DD testing for predicting patient outcomes.

Conclusions:

Plasma D-dimer levels are not a reliable tool for stroke diagnosis.
DD testing cannot substitute for clinical or radiological assessments in stroke care.
Current evidence does not support the use of DD for predicting stroke outcomes.