Related Experiment Video
Updated: Jul 2, 2026
09:07
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
Orthotopic neobladder for bladder cancer and neurogenic bladder dysfunction
Matthew J Maurice1, Joshua J Meeks, Norm D Smith
1Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
The Canadian Journal of Urology
|August 19, 2008
Summary
Patients with neurogenic bladder (NGB) due to spinal cord injury (SCI) face higher bladder cancer risks. This study details the first successful orthotopic neobladder creation in an SCI patient with NGB and bladder cancer, enabling voiding via Valsalva maneuver.
Area of Science:
- Urology
- Oncology
- Neurosurgery
Background:
- Neurogenic bladder (NGB) in spinal cord injury (SCI) patients increases susceptibility to bladder cancer.
- Urinary diversion selection for NGB patients with bladder cancer is complex, influenced by individual factors and renal status.
Observation:
- A case study of a male patient with NGB secondary to SCI who developed bladder cancer.
- The patient underwent radical cystectomy and subsequent creation of an orthotopic neobladder.
Findings:
- The patient successfully voids using the Valsalva maneuver with the orthotopic neobladder.
- This represents the first reported instance of a successful orthotopic neobladder in a patient with NGB following radical cystectomy for bladder cancer.
Implications:
- Orthotopic neobladder may be a viable urinary diversion option for select NGB patients with bladder cancer.
- This approach could improve quality of life for SCI survivors by enabling more natural voiding function.
Related Concept Videos
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
01:23Urinary Bladder
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...