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Updated: Jul 2, 2026

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

[Antiangiogenics: new therapeutic standards in metastatic kidney cancer]

J-N Cornu1, M Rouprêt, K Bensalah

  • 1Service d'Urologie, Hôpital Pitié-Salpétrière, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalo-Universitaire Est, Faculté de médecine Pierre et Marie Curie, Université Paris VI, Paris, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|September 26, 2008
PubMed

Insights

Metastatic renal cell carcinoma treatment has evolved significantly since 2004 with targeted therapies. Antiangiogenic agents and mTOR inhibitors now offer improved survival outcomes for patients with advanced kidney cancer.

Area of Science:

  • Oncology
  • Medical treatment of cancer

Background:

  • Historically, metastatic renal cell carcinoma (mRCC) treatment relied on cytokines and nephrectomy.
  • Recent advancements have introduced targeted therapies, significantly altering mRCC management.

Purpose of the Study:

  • To review the evolution of mRCC treatment since 2004.
  • To highlight the role of novel antiangiogenic agents and mTOR inhibitors.

Main Methods:

  • Review of clinical studies and therapeutic strategies for mRCC.
  • Analysis of targeted therapies including antiangiogenic agents (VEGF, PDGF inhibitors) and mTOR inhibitors.

Main Results:

  • Antiangiogenic agents like sunitinib and sorafenib improve progression-free survival in mRCC.
  • mTOR inhibitors (Temsirolimus) offer benefits in overall survival for specific mRCC subtypes.
  • Bevacizumab targets VEGF, representing another therapeutic option.

Conclusions:

  • New targeted therapies have revolutionized mRCC treatment, improving patient outcomes.
  • The optimal sequencing of these novel agents requires further definition.
  • Managing side effects associated with these potent therapies is crucial.

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