Related Experiment Video
Updated: Jul 2, 2026

The Immediate Partial Removal of Cumulus-Oocyte Complexes: A Refined Approach for Rapid Observation of In Vitro Fertilization
Published on: October 18, 2024
Comparison of protocols efficacy in poor responders: differences in oocytes/embryos competence with different
Massimo Manno1, Francesco Tomei, Marta Cervi
1Maternal-Pediatric Department, Pordenone Hospital, Pathophysiology Unit of Human Reproduction and Sperm Bank, Pordenone, Italy. massimo.manno@aopn.fvg.it
Abstract:
At present, there is no agreement on poor ovarian response definition, and no definitive evidence that this prognosis can be changed by a specific protocol. Our data suggest that a flare-up protocol with a depot gonadotropin-releasing hormone (GnRH) agonist formulation gives higher total pregnancy and implantation rates than a GnRH antagonist, possibly by improving oocyte/embryo competence.
