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Benzene and Pituitary-Thyroid Axis in Workers Exposed to Urban Pollution
Grazia Giammichele1, Lucio Montuori1, Carmina Sacco1,2
1From the SiPro Sicurezza e Produttività nel Lavoro, Rome, Italy (G.G., L.M., C.S, S.C., R.M., F.C., A.S., F.T., S.M.).
Objective:
The aim of this study is to verify if outdoor workers' exposure to low dose of benzene in urban air may affect thyroid hormone levels.
Methods:
The study was conducted on a total sample of 334 subjects. Benzene's environmental monitoring has been performed through personal dosimeters, whereas, for the biological monitoring, we have measured the concentration of blood benzene, trans,trans-muconic acid (t,t-MA) urinary, and S-phenylmercapturic acid (S-PMA) urinary on thyroid hormones. The statistical analysis was performed.
Results:
Statistic test shows that there is a negative correlation between blood benzene levels, t,t-MA urinary, FT3, and FT4; there is a positive correlation between blood benzene, t,t-MA urinary, and TSH.
Conclusions:
Occupational exposure to low dose of benzene in urban pollution can affect thyroid hormone levels in occupationally exposed workers.
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