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Updated: Jul 2, 2026
12:32
EPA Method 1615. Measurement of Enterovirus and Norovirus Occurrence in Water by Culture and RT-qPCR. Part III. Virus Detection by RT-qPCR
Published on: January 16, 2016
The structure-function relationship of the enterovirus 3'-UTR.
Jan Zoll1, Hans A Heus, Frank J M van Kuppeveld
1Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Department of Medical Microbiology, PO Box 9101, 6500 HB Nijmegen, The Netherlands. j.zoll@ncmls.ru.nl
Virus Research
|August 19, 2008
Summary
This review explores RNA elements in the 3'-UTR of enteroviruses, crucial for viral replication. These structures are key components of macromolecular machines, influencing viral assembly and activity.
Area of Science:
- Molecular Biology
- Virology
- Structural Biology
Background:
- Essential cellular processes rely on large macromolecular machines, often comprising proteins and nucleic acids like RNA.
- RNA's structure dictates its functionality, including stability, interactions, catalytic activity, and regulation of cellular processes.
- Viral RNA molecules possess complex structures that act as regulatory elements for processes like genome replication.
Purpose of the Study:
- To review the role of RNA elements within the 3 -untranslated region (UTR) of enteroviruses.
- To highlight the importance of these RNA structures in viral replication mechanisms.
Main Methods:
- Literature review focusing on enterovirus 3 -UTR RNA elements.
- Analysis of structural features and their functional implications in viral replication.
Main Results:
- Enterovirus RNA replication involves a biomolecular complex formed by cis-acting RNA elements in the 5 - and 3 -UTRs and associated proteins.
- The 3 -UTR of enteroviruses contains complex, multidomain RNA structures essential for viral processes.
- These structures are involved in specific ligand recognition and maintaining the integrity of viral replication machinery.
Conclusions:
- RNA elements in the 3 -UTR are critical for enterovirus replication.
- The structural complexity of these RNA elements underpins their functional roles in the viral life cycle.
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