Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pneumothorax II: Pathophysiology

Pneumothorax II: Pathophysiology

Pneumothorax means the presence of air in the pleural space — the thin potential gap between the visceral and parietal pleura. This condition disrupts the normal pressure balance that keeps the lungs inflated, leading to partial or complete collapse of the affected lung.Normal physiologyUnder normal conditions, the pleural space maintains a slightly negative intrapleural pressure, which keeps the lungs expanded against the chest wall. This negative pressure creates a delicate balance between...

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

Atelectasis II: Pathophysiology

Atelectasis II: Pathophysiology

Atelectasis develops when alveoli lose their air and collapse inward. Because lung tissue is naturally elastic, these air sacs shrink rather than remaining open. Collapsed alveoli are no longer ventilated, reducing their role in gas exchange. Blood flow may continue in these regions, creating a ventilation–perfusion mismatch. Clinical findings include decreased breath sounds, dullness to percussion, reduced chest expansion, and decreased tactile fremitus as sound transmission through collapsed...

Cardiopulmonary Resuscitation II: ACLS Airway Management

Cardiopulmonary Resuscitation II: ACLS Airway Management

Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned under...

Pneumothorax-I

Pneumothorax-I

A pneumothorax is a condition where air builds up in the space between the lung and the chest wall, causing the lung to collapse. This condition arises when air enters the space between the parietal and visceral pleura, disrupting the negative pressure essential for lung inflation. This can lead to a partial or complete collapse of the lung.
Pneumothorax can be even further classified as spontaneous, traumatic, and tension pneumothorax.

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal Perforation-II: Clinical Manifestations and Management

Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Erratum: "Anisotropic coarse-grain Monte Carlo simulations of lysozyme, lactoferrin, and NISTmAb by precomputing atomistic models" [J. Chem. Phys. 161, 094113 (2024)].

The Journal of chemical physics·2026

Same author

From Intermolecular Poses to Thermodynamics Using Subdivided Spheres.

The journal of physical chemistry. B·2026

Same author

Novel minimal invasive antireflux techniques: A systematic review.

Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society·2025

Same author

HemoDens: A global hemostasis analyzer for kinetic characterization of clot formation, retraction, and lysis.

Thrombosis research·2025

Same author

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2025

Same author

Evaluation of MRX PT DOAC as a new screening method for detecting interferences in thrombophilia analyses.

Scandinavian journal of clinical and laboratory investigation·2025

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

One-lung ventilation during thoracoabdominal esophagectomy elicits complement activation.

Jon A Tsai¹, Mikael Lund, Lars Lundell

¹Division of Surgery, CLINTEC, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden. jon.tsai@ki.se

The Journal of Surgical Research

|August 19, 2008

Summary

One-lung ventilation (OLV) during esophagectomy increases inflammatory markers, specifically terminal complement complex (TCC), compared to two-lung ventilation (TLV). This augmented inflammatory response may contribute to postoperative respiratory distress.

More Related Videos

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Related Experiment Videos

Last Updated: Jul 2, 2026

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Normothermic Negative Pressure Ventilation Ex Situ Lung Perfusion: Evaluation of Lung Function and Metabolism

Published on: February 14, 2022

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

Area of Science:

Anesthesiology
Immunology
Thoracic Surgery

Background:

One-lung ventilation (OLV) during esophagectomy may trigger inflammatory responses, potentially leading to postoperative respiratory distress.
Inflammation and tissue damage are hypothesized as key pathways in OLV-induced complications.

Purpose of the Study:

To investigate whether one-lung ventilation (OLV) induces an inflammatory cascade during thoracoabdominal esophagectomy.
To compare inflammatory and coagulation markers between OLV and two-lung ventilation (TLV) groups.

Main Methods:

Thirty patients undergoing esophagectomy were randomized to OLV (n=16) or TLV (n=14).
Inflammatory and coagulation markers, including interleukin-6, thrombin-antithrombin complexes, C3a, and terminal complement complex (TCC), were measured perioperatively and postoperatively.

Main Results:

Interleukin-6 and thrombin-antithrombin complexes increased perioperatively but showed no difference between OLV and TLV groups.
Terminal complement complex (TCC) levels increased postoperatively, with a significantly higher elevation in the OLV group compared to the TLV group.
C3a levels increased similarly in both OLV and TLV groups.

Conclusions:

One-lung ventilation (OLV) is associated with an enhanced inflammatory response, indicated by elevated terminal complement complex (TCC) activation.
This augmented inflammatory response during OLV may contribute to pulmonary tissue damage and inflammatory cell recruitment, potentially increasing the risk of postoperative respiratory distress.