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[Effects of preoperative ketamine on postoperative pain in patients undergoing laparotomy]
Takayuki Kitamura1, Gaku Kawamura, Shoko Iwanaga
1Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
Background:
Effects of preoperative ketamine on postoperative pain in patients undergoing laparotomy have been controversial.
Methods:
Fifty-two patients undergoing elective laparotomy were enrolled in this retrospective study. Patients were classified into 3 groups according to anesthetic management; patients received general anesthesia alone with preoperative ketamine (n = 20), patients received epidural blockade and general anesthesia with preoperative ketamine (n = 15), and patients received epidural blockade and general anesthesia without preoperative ketamine (n = 17). Among the three groups, we compared the parameters concerning postoperative pain managements; frequency of complaining about pain, opioid consumption, incidence of nausea and vomiting in the first 24 hours after laparotomy, and ability of ambulation on the first postoperative day.
Results:
Among the three groups, there were no significant differences in all parameters concerning postoperative pain management described above.
Conclusions:
Results of this study imply that preoperative ketamine may elicit preemptive analgesic effects, and can be an efficient adjuvant to postoperative pain management for patients undergoing laparotomy.
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