Related Experiment Video
Updated: Jul 2, 2026

A Strategy for Sensitive, Large Scale Quantitative Metabolomics
Published on: May 27, 2014
Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid
Jia Hao1, Pu Zhang, Xiaoan Wen
1Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China.
Abstract:
An efficient access to 2-isobetulin, 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid has been developed. The key step is a novel one-pot conversion of 2,3-dihydroxy triterpenes to 3-deoxy-2-oxo triterpenes. This method provides a new access to 3-deoxy-2-substituted pentacyclic triterpenes as potential therapeutic agents against metabolic diseases, tumors, and HIV infection.
More Related Videos
Related Concept Videos
Carboxylic Acid Derivatives: Overview
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
α-Hydroxy Ketones via Reductive Coupling of Esters: Acyloin Condensation Overview
Alkylation of β-Diester Enolates: Malonic Ester Synthesis
Direct-Acting Cholinergic Agonists: Pharmacokinetics
Preparation of Diols and Pinacol Rearrangement
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.

