Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase01:27

Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Bovis calculus sativus improves cognitive function after ischemic stroke by regulating PKA/CREB/Sirt1/eIF2α signaling pathway" [J. Ethnopharmacol. 354 (2026) 120509].

Journal of ethnopharmacology·2026
Same author

Methylated PIH1D1 as a Heart-Specific Biomarker for Anthracycline-Induced Cardiac Remodeling in Breast Cancer Patients.

JACC. Basic to translational science·2026
Same author

X-Ray Repair Cross-Complementing Group 1 Genetic Polymorphisms and the Risk of Sudden Sensorineural Hearing Loss.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2026
Same author

Effects of Changes in Metabolic Syndrome Status on Cognitive Function: A 10-Year Study in a Middle-Aged Population.

The Kaohsiung journal of medical sciences·2025
Same author

Low Geriatric Nutritional Risk Index Predicts Unfavorable Outcomes in Older Sudden Sensorineural Hearing Loss Patients.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2025
Same author

The RElationship of Advanced Education and ADherence (ReAHEAD) on antithrombotic in younger patients with non-valvular atrial fibrillation in Taiwan.

Journal of the Formosan Medical Association = Taiwan yi zhi·2025

Related Experiment Video

Updated: Jul 2, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

Matrix metalloproteinase-2 gene polymorphisms in nasal polyps.

Ling-Feng Wang1, Chen-Yu Chien, Wen-Rei Kuo

  • 1Department of Otolaryngology, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Archives of Otolaryngology--Head & Neck Surgery
|August 20, 2008
PubMed
Summary

Matrix metalloproteinase-2 (MMP2) gene variants do not appear to significantly increase the risk of developing nasal polyps in the Taiwanese population. Further research is needed to understand the genetic factors involved in this condition.

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
07:00

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas

Published on: February 28, 2019

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

Area of Science:

  • Genetics
  • Otorhinolaryngology
  • Molecular Biology

Background:

  • Nasal polyps are inflammatory growths in the nasal cavity.
  • The role of specific genes, such as matrix metalloproteinase-2 (MMP2), in polyp development is not fully understood.
  • Genetic variations may influence susceptibility to nasal polyps.

Purpose of the Study:

  • To investigate the association between MMP2 gene single nucleotide polymorphisms (SNPs) and nasal polyp development.
  • To examine the role of a functional promoter SNP in MMP2 in a Taiwanese population.
  • To determine if MMP2 genetic variations contribute to the risk of chronic rhinosinusitis with nasal polyps.

Main Methods:

  • A case-control study was conducted with 136 nasal polyp cases and 136 controls.
  • Seventeen MMP2 SNPs, including tagging and promoter SNPs, were genotyped using TaqMan technology.
  • Statistical analyses included Hardy-Weinberg equilibrium testing, genetic effect evaluation, and subset analysis for recurrent nasal polyps.

Main Results:

  • All analyzed SNPs were in Hardy-Weinberg equilibrium.
  • No significant association was found between MMP2 SNPs and nasal polyp risk after adjusting for sample size.
  • An initially significant finding for SNP rs857403 was deemed a false positive upon inclusion of additional controls.

Conclusions:

  • The MMP2 gene is unlikely to play a significant role in the pathogenesis of nasal polyps in the Taiwanese population.
  • The study did not identify any crucial genetic risk factors related to MMP2 for nasal polyp development.
  • Further investigation into other genetic pathways is warranted.