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Related Concept Videos

Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
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Transmission-based Precautions I: Contact, Enteric, and Droplets

Transmission-based precautions are for patients known to be infected or suspected to be infected or colonized with organisms that pose a significant risk to others. Some transmission-based precautions include contact, enteric, and droplet.
Contact Precautions:
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Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Transmission of Pathogens01:24

Transmission of Pathogens

Pathogens spread from their reservoirs to susceptible hosts through three main routes: contact transmission, vehicle transmission, and vector transmission. Each route involves distinct mechanisms of transfer.Contact TransmissionThis category includes direct contact, indirect contact, and droplet transmission:Direct contact involves immediate physical interaction between individuals—such as a handshake—which can spread pathogens like Streptococcus pyogenes, the bacterium responsible for...
Special Features of Adaptive Immunity01:20

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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
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Published on: November 16, 2016

Tolerance can be infectious.

Herman Waldmann1

  • 1Sir William Dunn School of Pathology, Oxford OX1 3RE, UK. herman.waldmann@path.ox.ac.uk

Nature Immunology
|August 20, 2008
PubMed
Summary
This summary is machine-generated.

Researchers revived the concept of suppressor T cells to achieve transplant tolerance. These crucial immune cells, once dismissed, are now confirmed to exist and play a key role.

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Area of Science:

  • Immunology
  • Transplantation Biology

Background:

  • Transplant tolerance is a major goal in organ transplantation.
  • The existence and function of suppressor T cells were previously debated.

Purpose of the Study:

  • To investigate the role of suppressor T cells in achieving transplant tolerance.
  • To re-evaluate historical concepts of immune suppression in transplantation.

Main Methods:

  • Review of historical immunological studies.
  • Analysis of contemporary research on T cell subsets.

Main Results:

  • The concept of suppressor T cells has been validated by modern research.
  • These cells are now recognized as critical for immune regulation.

Conclusions:

  • Suppressor T cells are essential for inducing and maintaining transplant tolerance.
  • Further research into these cells could lead to improved transplant outcomes.