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Updated: Jul 2, 2026
12:04
Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
Published on: October 3, 2018
The classification of protein domains
Russell L Marsden1, Christine A Orengo
1Biochemistry and Molecular Biology Department, University College London, London, United Kingdom.
Methods in Molecular Biology (Clifton, N.J.)
|August 21, 2008
Summary
Protein classification organizes vast sequence and structure data, revealing evolutionary insights and functional diversity across life. This approach enhances genomic understanding through domain family annotations.
Area of Science:
- Proteomics
- Bioinformatics
- Genomics
Background:
- Rapid growth in protein sequence and structure data necessitates organization.
- Understanding protein evolution, function, and diversity across life kingdoms is crucial.
Purpose of the Study:
- To discuss methods for protein classification, focusing on protein domains.
- To explore the construction of domain sequence and structure databases.
- To demonstrate how domain annotations improve genomic insights.
Main Methods:
- Review of common protein classification approaches.
- Emphasis on protein domain classification techniques.
- Consideration of domain sequence and structure database construction.
Main Results:
- Development of diverse protein family classification systems.
- Creation of domain sequence and structure databases.
- Utilization of domain family annotations for structural and functional assignments.
Conclusions:
- Protein classification provides order to biological data.
- Domain-based classification enhances understanding of protein evolution and function.
- Domain annotations are key to interpreting genomic information.
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02:26Conservation of Protein Domains Over Different Proteins
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
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The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the anterior...
02:26Conservation of Protein Domains
Protein domains are small structurally independent units that are part of a single amino acid chain. Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
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02:47Protein Families
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...
01:13Protein Organization
Overview