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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jul 2, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

[Correlation between structural and functional analysis in glaucoma suspects].

D Chiseliţă1, C Danielescu, Alina Apostol

  • 1Clinica I Oftalmologie, Iaşi.

Oftalmologia (Bucharest, Romania : 1990)
|August 22, 2008
PubMed
Summary
This summary is machine-generated.

Structural and functional eye damage in early glaucoma show poor correlation. Both optical coherence tomography (OCT) and scanning laser polarimetry (GDx) tests should be used alongside visual field exams for accurate diagnosis.

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Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation
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Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation

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Last Updated: Jul 2, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

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Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation
07:11

Functional Magnetic Resonance Imaging (fMRI) of the Visual Cortex with Wide-View Retinotopic Stimulation

Published on: December 8, 2023

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma diagnosis relies on detecting structural and functional damage.
  • Early detection is crucial for managing glaucoma and preventing vision loss.
  • Correlating structural measurements with functional tests aids diagnostic accuracy.

Purpose of the Study:

  • To investigate the relationship between structural parameters and functional vision in glaucoma suspects.
  • To evaluate the diagnostic concordance of different imaging techniques with visual field testing.

Main Methods:

  • Standard automated perimetry was conducted.
  • Retinal nerve fiber layer (RNFL) and optic disc were assessed using optical coherence tomography (OCT).
  • Scanning laser polarimetry (GDx-VCC) was used to measure RNFL thickness.

Main Results:

  • Diagnostic concordance between perimetry and OCT was 60.24%; between perimetry and GDx was 61.44%.
  • Area Under the Curve values for OCT and GDx parameters ranged from 0.518 to 0.574.
  • Correlation coefficients between OCT and GDx RNFL measurements were between 0.352 and 0.481.

Conclusions:

  • Structural and functional damage in early glaucoma are not consistently correlated.
  • Both OCT and GDx, in conjunction with visual field testing, are recommended for a comprehensive diagnostic strategy.