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Updated: Jul 2, 2026
06:01
A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
Published on: July 6, 2017
[Prophylactic colectomy in hereditary colorectal cancer]
Bruno Buecher1, Pierre Laurent-Puig
1Département de génétique, unité d'oncogénétique, Hôpital européen Georges-Pompidou, 75908 Paris Cedex 15, France. bruno.buecher@egp.aphp.fr
La Revue Du Praticien
|August 22, 2008
Summary
Hereditary colorectal cancer requires intensive endoscopic surveillance and removal of all lesions. Colectomy is indicated for unresectable or numerous polyps, especially in familial adenomatous polyposis.
Area of Science:
- Gastroenterology and Oncology
- Colorectal Surgery
Context:
- Hereditary colorectal cancer syndromes present a significantly elevated lifetime risk of colorectal cancer.
- These conditions necessitate rigorous endoscopic surveillance protocols.
Purpose:
- To outline management strategies for colorectal lesions in hereditary cancer syndromes.
- To define indications for endoscopic resection versus colectomy.
Summary:
- Endoscopic removal is recommended for all identified colorectal lesions during surveillance.
- Colectomy is considered for lesions unsuitable for endoscopic resection due to morphology or multiplicity.
- Colectomy or coloproctectomy is virtually always indicated for classical familial adenomatous polyposis patients due to extensive polyp development.
Impact:
- Informs clinical decision-making for managing high-risk individuals.
- Emphasizes the importance of multidisciplinary team discussion and specialized surgical centers for optimal patient outcomes.
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