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Related Experiment Video

Updated: Jul 2, 2026

Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles
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Protein Kinase C-delta Inhibitor Peptide Formulation using Gold Nanoparticles

Published on: March 9, 2019

Functional gold nanoparticle-peptide complexes as cell-targeting agents.

Linlin Sun1, Dianjun Liu, Zhenxin Wang

  • 1State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.

Langmuir : the ACS Journal of Surfaces and Colloids
|August 22, 2008
PubMed
Summary
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Researchers developed peptide-functionalized gold nanoparticles for targeted intracellular delivery. Nanoparticle size and peptide coverage control cellular component targeting and cell viability, enabling unique colorimetric expressions.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cell Biology

Background:

  • Gold nanoparticles (AuNPs) offer versatile platforms for biomedical applications.
  • Targeting intracellular components requires precise control over nanoparticle delivery and localization.
  • Peptide functionalization is a key strategy for directing nanoparticle behavior within cells.

Purpose of the Study:

  • To investigate the use of peptide CALNN and its derivative CALNNR(8) for functionalizing gold nanoparticles.
  • To determine how nanoparticle diameter and peptide surface coverage influence intracellular targeting.
  • To explore the impact of these functionalized nanoparticles on cell viability and intracellular distribution.

Main Methods:

  • Synthesis and functionalization of gold nanoparticles with peptide CALNN and CALNNR(8).

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  • Varying nanoparticle diameter and CALNNR(8) surface density for controlled experiments.
  • Utilizing fluorescent confocal scanning laser microscopy to track intracellular distribution and fluorescence quenching.
  • Assessing cell viability following internalization of the gold nanoparticle-peptide complexes.

    • Main Results:

    • Nanoparticle translocation from the nucleus to the endoplasmic reticulum was achieved by increasing CALNNR(8) density.
    • Increased nanoparticle diameter at constant peptide density reduced cellular internalization.
    • Internalized nanoparticle-peptide complexes affected cell viability based on quantity per cell.
    • Colorimetric changes in cell structures were observed due to nanoparticle translocation.

    Conclusions:

    • Peptide-functionalized gold nanoparticles provide a tunable platform for intracellular targeting.
    • Nanoparticle size and peptide density are critical parameters for controlling intracellular distribution and uptake.
    • This approach offers potential for novel diagnostic and therapeutic strategies through targeted delivery and visualization.