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Related Concept Videos

Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Accessory Structures of the Skin: Sebaceous Glands01:21

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

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Related Experiment Video

Updated: Jul 2, 2026

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System
04:37

Generation of Human Induced Pluripotent Stem Cell-derived Planar Hair-bearing Skin Organoids Using an Air-Liquid Interface Culture System

Published on: October 17, 2025

Lichen planopilaris.

Hoon Kang1, Abdullateef A Alzolibani, Nina Otberg

  • 1Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada. johnkang@catholic.ac.kr

Dermatologic Therapy
|August 22, 2008
PubMed
Summary
This summary is machine-generated.

Lichen planopilaris is a chronic scarring alopecia causing scalp inflammation and hair loss. While definitive cures remain elusive, ongoing research expands treatment options for this condition.

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Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia
03:22

Mechanical and Controlled PRP Injections in Patients Affected by Androgenetic Alopecia

Published on: January 27, 2018

Area of Science:

  • Dermatology
  • Trichology

Background:

  • Lichen planopilaris is a chronic scarring alopecia.
  • It presents with follicular hyperkeratosis, perifollicular erythema, and loss of follicular orifices.
  • Symptoms include hair shedding, itching, scaling, burning, and tenderness.

Purpose of the Study:

  • To provide a comprehensive overview of lichen planopilaris.
  • To discuss diagnostic criteria and differential diagnoses.
  • To review current and emerging treatment strategies.

Main Methods:

  • Clinical evaluation of scalp lesions.
  • Histopathologic examination of skin biopsies.
  • Immunohistopathologic analysis.

Main Results:

  • Lichen planopilaris characteristically involves the vertex and parietal scalp.
  • Anagen hairs are easily epilated from active lesions.
  • Associated cutaneous, nail, and mucous membrane lichen planus may be present.

Conclusions:

  • Accurate diagnosis relies on clinical and histopathologic findings.
  • Treatment is tailored to disease activity and physician expertise.
  • While not curable, new discoveries are improving management of lichen planopilaris.