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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography
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ThinPrep vitreous-based diagnosis of choroidal malignant melanoma
Annie Chan1, Peter R Egbert, Darius M Moshfeghi
1Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, USA.
Purpose:
To report an alternative method for the diagnosis of atypical choroidal malignant melanoma-ThinPrep sampling of the vitreous cavity through 25-gauge vitrectomy.
Method:
Case report.
Results:
A 79-year-old gentleman presented with a progressive decline in visual acuity in his left eye. A clinical diagnosis of large choroidal malignant melanoma was made. Given the history of trauma and the possibility of enucleation, the patient wished to have histopathological confirmation. The patient underwent 25-gauge vitrectomy. However, he developed a choroidal hemorrhage during the procedure and the surgeon elected not to perform transretinal biopsy. Instead a sample of the vitreous was evaluated by ThinPrep analysis, and a diagnosis of choroidal malignant melanoma was made.
Conclusions:
Cytological evaluation of vitreous substance with ThinPrep may provide an alterative method for a diagnosis in select cases in which FNA is not possible or desirable. This technique is straightforward and minimizes the risk of retinal detachment or hemorrhage.
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