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Related Experiment Video

Updated: Jul 2, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

[The relationship between RUNX3 gene mutation and keloid].

Gang Zhang¹, Jun-Jian Jiang, Shao-Jun Luo

¹Institute of Plastic Surgery, Guangdong Medical College, Zhanjiang 524001, China.

Zhonghua Zheng Xing Wai Ke Za Zhi = Zhonghua Zhengxing Waike Zazhi = Chinese Journal of Plastic Surgery

|August 23, 2008

Summary

RUNX3 gene mutations are highly prevalent in Chinese keloid patients, with 95% showing alterations in the RH120480 fragment. These findings suggest RUNX3 may function as a scar suppressor gene, offering potential therapeutic targets.

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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

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Published on: September 1, 2019

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Last Updated: Jul 2, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

Area of Science:

Genetics
Dermatology
Molecular Biology

Context:

Keloids are abnormal scars resulting from excessive collagen deposition.
Genetic factors are implicated in keloid pathogenesis, but specific genes remain largely unidentified.

Purpose:

To investigate mutations in the RH120480 fragment of the RUNX3 gene in Chinese patients with keloid.
To determine the correlation between RUNX3 gene mutations and keloid formation.

Summary:

Genomic DNA from 20 keloid tissues and 20 blood samples was analyzed.
Polymerase Chain Reaction (PCR) and denaturing high-performance liquid chromatography (DHPLC) identified mutations.
Gene sequencing revealed a 95% mutation rate in keloid samples, with two specific mutation sites identified.

Impact:

The study identified a strong correlation between RUNX3 gene mutations and keloid development.
RUNX3 is proposed as a potential scar suppressor gene (SSG).
Findings may pave the way for novel diagnostic and therapeutic strategies for keloids.