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Cosmetic acceptability of six 40-50% urea preparations: a single-blind, pilot study
William Stebbins1, Andrew Alexis, Jacob Levitt
1Department of Dermatology, The Mount Sinai School of Medicine, New York, NY, USA.
Background:
Urea 40-50% is widely used in the treatment of hyperkeratotic dermatoses. Compliance with topical therapy is directly related to the esthetic and sensory acceptability of a topical agent.
Objective:
To assess the spreadability, odor, and post-application residue of 0.1 mL of six different urea 40-50% preparations administered in single-blind fashion to 12 trained female panelists.
Methods:
Spreadability was assessed at time 0, and odor and residue were assessed at 30 minutes post-application. The scores for a novel emollient preparation were compared with the composite scores of five existing preparations.
Results:
The novel emollient preparation was found to be the most spreadable and to leave the least residue. Odor scores were comparable and low overall.
Conclusion:
Urea 40-50% preparations may vary considerably in odor, spreadability, and post-application residue. The novel emollient preparation was the most cosmetically acceptable.
