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Updated: Jul 2, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases

Published on: June 22, 2012

Sickle red cell-endothelium interactions.

Dhananjay K Kaul¹, Eileen Finnegan, Gilda A Barabino

¹Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. kaul@aecom.yu.edu

Microcirculation (New York, N.Y. : 1994)

|August 23, 2008

Summary

Sickle cell disease involves painful crises due to red blood cell adhesion. This review explores mechanisms of sickle red cell adhesion and potential therapies targeting these interactions.

Area of Science:

Hematology
Vascular Biology
Cellular Adhesion

Background:

Sickle cell disease (SCD) is characterized by recurrent vaso-occlusive crises.
Sickle red blood cell adhesion to the endothelium is a key factor in vaso-occlusion.

Purpose of the Study:

To review the mechanisms of human sickle red blood cell adhesion.
To discuss the role of cellular interactions and adhesion molecules in SCD pathogenesis.
To analyze therapeutic strategies targeting adhesion molecules and endothelial activation.

Main Methods:

Review of in vitro and microcirculatory findings.
Analysis of receptor-ligand interactions.
Examination of data from transgenic sickle mouse models.

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Main Results:

Sickle red cell-endothelium interaction is a primary mechanism in vaso-occlusion.
Leukocyte recruitment and interactions also contribute to vaso-occlusion.
Novel adhesion molecules significantly mediate sickle red cell adhesion.

Conclusions:

Understanding sickle red cell adhesion mechanisms is crucial for SCD treatment.
Targeting adhesion molecules offers a promising therapeutic avenue.
Inhibiting endothelial activation can prevent vaso-occlusive events.