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Updated: Jul 2, 2026

Isolation and Chemical Characterization of Lipid A from Gram-negative Bacteria
Published on: September 16, 2013
[Structure and function of lipopolysaccharide lipid A in bacteria--a review]
1State Key Laboratory of Food Science and Technology, Key Laboratory of Industrial Biotechnology of the Ministry of Education, Jiangnan University, Wuxi, 214122. liyanyan1123@163.com
Abstract:
Lipid A, the hydrophobic group of lipopolysaccharide, covers the surface of most Gram-negative bacteria. Lipopolysaccharide, known as endotoxin, can cause fatal disease like sepsis syndrome. Recent studies have shown that it is only the lipid A part of lipopolysaccharide that has the function of endotoxin. After entering the human body, lipid A on the surface of bacteria can stimulate the Toll-like-receptor 4 on the surface of host cells, cause a series of reaction, and produce different cytokines. Here we have discussed the structure, biosynthesis and pathogenesis of lipid A. The application of lipid A in vaccine development was proposed.
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