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Updated: Mar 3, 2026

Methods to Identify the NMR Resonances of the 13C-Dimethyl N-terminal Amine on Reductively Methylated Proteins
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N-Monomethylation of amines using paraformaldehyde and H2

Hongli Wang1, Yongji Huang, Xingchao Dai

  • 1State Key Laboratory for Oxo Synthesis and Selective Oxidation, Centre for Green Chemistry and Catalysis, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No. 18, Tianshui Middle Road, Lanzhou, P. R. China. fshi@licp.cas.cn.

Chemical Communications (Cambridge, England)
|May 5, 2017
PubMed
Summary

This study introduces a novel method for selective N-monomethylation of amines using paraformaldehyde and hydrogen gas with a CuAlOx catalyst. The reaction is effective for various primary and secondary amines in fine chemical synthesis.

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