Related Experiment Video
Updated: Jul 2, 2026

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Protective ventilation in ARDS: as soon as possible. An immediate use of HFOV
Philippe Ph Goutorbe1, Yves Y Asencio, Julien J Bordes
1Military teaching hospital Sainte Anne ICU department, Toulon, France. goutorbephil@live.fr.
Objective:
To report the immediate use of High-Frequency Oscillatory ventilation in an adult acute respiratory distress syndrome.
Design:
Case report.
Setting:
Intensive care unit at the Military Teaching Hospital of Toulon.
Patient:
A 64-yr-old Caucasian male who developed acute respiratory distress syndrome in the course of severe falciparum malaria.
Intervention:
Initial use of HFO to minimise ventilator-induced lung injury.
Measurement And Main Results:
Rapid improvement of PaO2/fraction of inspired oxygen from 172 mmHg (NIV) to 310 mmHg with HFO. No ventilator-induced injury on CT scan after 5 days of invasive ventilation.
Conclusion:
In contrast with previous studies, we successfully used lung protective ventilation with HFO immediately. Further studies, with immediate, rather than rescue use of HFO ventilation, are needed.
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