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Related Concept Videos

Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Regurgitation III: Medical Management01:25

Mitral Regurgitation III: Medical Management

Mitral regurgitation (MR) is characterized by retrograde blood circulation from the left ventricle into the left atrium due to inadequate mitral valve closure. The severity of the condition, symptoms, and underlying cause determine treatment strategies.Monitoring and Pharmacological TreatmentPatients with mild to moderate MR typically do not need immediate intervention but regular monitoring to assess progression and guide treatment. Patients with mild MR should have an echocardiogram every 3-5...

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Related Experiment Video

Updated: Jul 2, 2026

Transcatheter Pulmonary Valve Replacement from Autologous Pericardium with a Self-Expandable Nitinol Stent in an Adult Sheep Model
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Transapical mitral valved stent implantation.

Lucian Lozonschi1, Rene Quaden, Niloo M Edwards

  • 1Department of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

The Annals of Thoracic Surgery
|August 30, 2008
PubMed
Summary

Transapical off-pump mitral valved stent implantation is feasible in pigs, showing stable hemodynamics post-procedure. Further research is needed to establish the long-term function of this novel valved stent.

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Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Interventional Cardiology

Background:

  • Transcatheter aortic and pulmonary valve replacement are under investigation.
  • Atrioventricular valved stent development faces challenges due to complex cardiac anatomy and function.
  • Novel approaches are needed for less invasive valve replacement.

Purpose of the Study:

  • To evaluate the feasibility and acute safety of a self-expanding valved stent for transapical atrioventricular valve replacement.
  • To assess the hemodynamic stability and device function following mitral valved stent implantation in an animal model.

Main Methods:

  • A self-expanding valved stent was designed for transapical mitral valve replacement.
  • Ten pigs underwent transapical off-pump mitral valved stent implantation.
  • Hemodynamic stability, stent positioning, and function were assessed using echocardiography and ventriculography.

Main Results:

  • All animals demonstrated immediate and sustained hemodynamic stability post-implantation.
  • Accurate positioning of the valved stent was achieved in all subjects.
  • Mild paravalvular regurgitation was observed in a subset of animals; no left ventricular outflow tract obstruction occurred.

Conclusions:

  • Transapical off-pump mitral valved stent implantation is a feasible acute procedure in an experimental setting.
  • The study confirms the potential of this technique for mitral valve replacement.
  • Long-term efficacy and durability of the valved stent require further investigation.