Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gene Conversion

Gene Conversion

Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...

Duplication of Chromatin Structure

Duplication of Chromatin Structure

The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
The basic unit of the chromatin is the nucleosome, consisting of DNA wrapped around octameric histone proteins and short stretches of linker DNA separating individual nucleosomes. The histone proteins within the nucleosome have their...

Nucleosome Remodeling

Nucleosome Remodeling

Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...

The Nucleosome

The Nucleosome

Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...

The Nucleosome

The Nucleosome

DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...

Microtubule Instability

Microtubule Instability

Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated assembly and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mutant IDH1 blocks neutropoiesis by repressing myeloid progenitor programs.

Blood·2026

Same author

Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes.

Cancer cell·2026

Same author

Fiber intake associates with increased treatment response in patients with multiple myeloma along with changes in gut microbiome.

Blood advances·2026

Same author

Two distinct chromatin modules regulate proinflammatory gene expression.

Nature cell biology·2025

Same author

RBP2GO 2.0: Integrating disease associations and sequence features to explore RNA-binding protein functions.

Nucleic acids research·2025

Same author

Current practices in the study of biomolecular condensates: a community comment.

Nature communications·2025

Same journal

Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Molecular Basis of Disease Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

General Subjects Cumulative Contents.

Biochimica et biophysica acta·2020

Same journal

Erratum to 'on the role of exchangeable hydrogen bonds for the kinetics of P680<sup>+·</sup> Q<sub>A</sub> <sup>-·</sup> formation and P680<sup>+·</sup> Pheo<sup>-·</sup> recombination in photosystem II' [Biochim. Biophys. Acta 1276 (1996) 35-44].

Biochimica et biophysica acta·2019

Same journal

Oligomeric state of the light-harvesting complexes B800-850 and B875 from purple bacterium Rubrivivax gelatinosus in detergent solution.

Biochimica et biophysica acta·2019

Same journal

Regulation of pigment content and enzyme activity in the cyanobacterium Nostoc sp. Mac grown in continuous light, a light-dark photoperiod, or darkness.

Biochimica et biophysica acta·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

Genome organization: balancing stability and plasticity.

Malte Wachsmuth¹, Maïwen Caudron-Herger, Karsten Rippe

¹European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, Meyerhofstr. 1, 69117 Heidelberg, Germany.

Biochimica Et Biophysica Acta

|August 30, 2008

Summary

This summary is machine-generated.

The genome must be stable yet adaptable for cellular function. This review explores genomic dynamics, experimental methods, and nuclear activities balancing stability and plasticity.

More Related Videos

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

In-Nucleus Hi-C in Drosophila Cells

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

Related Experiment Videos

Last Updated: Jul 2, 2026

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

3D Multicolor DNA FISH Tool to Study Nuclear Architecture in Human Primary Cells

Published on: January 25, 2020

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.

Published on: May 6, 2010

In-Nucleus Hi-C in Drosophila Cells

In-Nucleus Hi-C in Drosophila Cells

Published on: September 15, 2021

Area of Science:

Genomics
Cell Biology
Biophysics

Background:

Cells require genome stability to prevent functional compromise.
Genomes must also be plastic, dynamically reorganizing for diverse cellular states.
Genomic dynamics occur across multiple scales, from proteins to chromosomes and over time.

Purpose of the Study:

To review contributions to genome dynamics.
To describe experimental methods for studying these dynamics.
To discuss how nuclear activities balance genome stability and plasticity.

Main Methods:

Literature review of experimental studies on genome dynamics.
Analysis of techniques measuring genomic organization and movement.
Integration of findings on nuclear processes influencing genome structure.

Main Results:

Genomic dynamics involve contributions from various molecular and structural factors.
Experimental methods reveal genome organization across nanometer to micrometer scales.
Nuclear activities are crucial for maintaining genome stability and enabling plasticity.

Conclusions:

The cell navigates a balance between maintaining genome integrity and allowing dynamic reorganization.
Understanding genomic dynamics is key to comprehending cellular function and adaptation.
Future research should further elucidate the interplay between nuclear activities and genome plasticity.