Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyphenothrin disrupts the integrity of porcine trophectoderm and uterine luminal epithelial cell lines by inducing mitochondrial dysfunction and oxidative stress.

Chemosphere·2026
Same author

Tolylfluanid induces mitochondrial dysfunction through excessive ROS generation and inhibits cell growth in bovine mammary epithelial cells.

Environmental toxicology and pharmacology·2026
Same author

Gestational Obesity Impairs Maternal Glucose Metabolism in Post-Partum Ewes.

Animals : an open access journal from MDPI·2025
Same author

Uterine histotroph and conceptus development. V. Comparative analyses of arginine-mediated transcriptomic reprogramming in conceptus trophectoderm of pigs and sheep†.

Biology of reproduction·2025
Same author

Novel Aspects of the Physiology of Pregnancy in Domestic Ruminants.

Animals : an open access journal from MDPI·2025
Same author

Dietary Supplementation with L-Citrulline Between Days 1 and 60 of Gestation Enhances Embryonic Survival in Lactating Beef Cows.

Animals : an open access journal from MDPI·2025

Related Experiment Video

Updated: Jul 2, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
09:41

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Let's validate those cell lines

Fuller W Bazer, Lois A Salamonsen

    Biology of Reproduction
    |August 30, 2008
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity
    07:58

    An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity

    Published on: May 12, 2020

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
    12:35

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

    Published on: September 3, 2016

    Related Experiment Videos

    Last Updated: Jul 2, 2026

    An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
    09:41

    An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

    Published on: July 15, 2015

    An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity
    07:58

    An Automated Differential Nuclear Staining Assay for Accurate Determination of Mitocan Cytotoxicity

    Published on: May 12, 2020

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
    12:35

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

    Published on: September 3, 2016