Calcifying epithelial odontogenic tumor: report of two cases

Area of Science:

• Oral pathology
• Odontogenic neoplasms
• Head and neck oncology

Background:

• Calcifying epithelial odontogenic tumor (CEOT) is an uncommon benign odontogenic neoplasm, representing 0.4-3% of all odontogenic tumors.
• CEOT is characterized microscopically by sheets of epithelial cells, amyloid-like material, and calcifications.
• Malignant transformation and metastasis of CEOT are rare, but the lesion can exhibit local aggressiveness.

Observation:

• This study presents two rare cases of CEOT involving the hard palate in Indian patients.
• The tumors presented with significant facial alterations due to their location and growth.
• The Indian literature has limited reported cases of CEOT, with only one prior cytological report.

Findings:

• The two cases of CEOT in the hard palate demonstrate the tumor's capacity to cause substantial local tissue changes.
• Microscopic examination confirmed the characteristic features of CEOT, including epithelial cells, amyloid-like material, and calcifications.
• Despite its benign nature, the observed facial alterations underscore the locally aggressive potential of CEOT.

Implications:

• These cases highlight the importance of recognizing CEOT, particularly in the hard palate, due to its potential for local aggression and associated facial disfigurement.
• Appropriate surgical management and long-term follow-up are crucial for patients diagnosed with CEOT to prevent recurrence or complications.
• Further research and case reporting, especially from underrepresented regions like India, are needed to better understand the behavior and management of CEOT.