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09:12
Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae
Published on: January 17, 2014
Isolated frontal sinusitis due to Pseudallescheria boydii.
Vamseedhar Annam1, V S Athaniker, Balasaheb Ramalingappa Yelikar
1Department of Pathology, Sree Siddhartha Medical College and Research Centre, Tumkur, Karnataka, India. vamseedhar_a@yahoo.com
Indian Journal of Pathology & Microbiology
|August 30, 2008
Summary
This case study highlights recurrent sino-nasal fungal infections caused by Pseudallescheria boydii in a diabetic patient. Miconazole proved effective, emphasizing accurate P. boydii identification for successful treatment.
Area of Science:
- Mycology
- Infectious Diseases
- Otolaryngology
Background:
- Recurrent sino-nasal fungal infections pose diagnostic challenges.
- Pseudallescheria boydii (P. boydii) requires specific identification for targeted antifungal therapy.
- Diabetes mellitus can increase susceptibility to fungal infections.
Observation:
- A 33-year-old diabetic woman presented with recurrent sino-nasal fungal infection.
- Histological examination revealed characteristic P. boydii features, including intercalary conidia and chlamydoconidia, when fungal culture was inconclusive.
- The patient was treated with Miconazole, the primary antifungal agent for P. boydii.
Findings:
- Accurate identification of P. boydii is crucial for effective treatment.
- Histopathology is vital for diagnosing P. boydii infections, especially when cultures fail.
- Miconazole demonstrated efficacy in treating this P. boydii infection.
Implications:
- This case underscores the importance of considering P. boydii in refractory sino-nasal fungal infections.
- Histological identification methods should be employed when fungal cultures are negative.
- Prompt and accurate diagnosis leads to successful treatment outcomes and prevents recurrence.
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