Related Experiment Video
Updated: Jul 2, 2026
Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
Corneal-conjunctival squamous cell carcinoma
Ioannis T Papaioannou1, Maria P Melachrinou, Evaggelos G Drimtzias
1Department of Ophthalmology, School of Medicine, University of Patras, Patras, Greece.
Purpose:
To report an extremely rare case of an extensive conjunctival-corneal invasive squamous cell carcinoma.
Methods:
A healthy 68-year-old man referred to our department with a moderately elevated hyperemic nodular mass on his right ocular surface. The lesion was completely covering the corneal surface and involved the temporal limbus with bulbar conjunctiva. Surgical excision was performed with 2-mm tumor-free margins documented histologically and double-freeze cryotherapy was applied 360 degrees for inhibition of tumor recurrence.
Results:
Histopathologic examination showed a moderately differentiated squamous cell carcinoma. The patient achieved a complete excision with no evidence of recurrence during the follow-up period of 12 months.
Conclusions:
This case points out the potential for a total covering of the cornea by squamous cell carcinoma. Wide surgical excision and double freeze-thaw cryotherapy may decrease the recurrence.
