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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Updated: Jul 2, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Corneal-conjunctival squamous cell carcinoma.

Ioannis T Papaioannou¹, Maria P Melachrinou, Evaggelos G Drimtzias

¹Department of Ophthalmology, School of Medicine, University of Patras, Patras, Greece.

|August 30, 2008

Summary

This case report details an extremely rare instance of extensive conjunctival-corneal squamous cell carcinoma. Surgical excision combined with cryotherapy effectively treated the ocular tumor, preventing recurrence.

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Area of Science:

Ophthalmology
Oncology

Background:

Squamous cell carcinoma (SCC) of the conjunctiva is a relatively uncommon malignancy.
Extensive ocular surface SCC can present significant challenges in management and treatment.

Observation:

A case of a 68-year-old male with a nodular mass completely covering the cornea and involving the limbus and conjunctiva is presented.
The lesion was identified as a moderately differentiated squamous cell carcinoma upon histopathologic examination.

Findings:

Complete surgical excision with 2-mm tumor-free margins was achieved.
Adjuvant double-freeze cryotherapy was applied circumferentially to the ocular surface.
No evidence of tumor recurrence was observed during a 12-month follow-up period.

Implications:

This case highlights the potential for squamous cell carcinoma to extensively involve the entire cornea.
Aggressive surgical management coupled with cryotherapy may be an effective strategy to reduce recurrence rates for extensive ocular SCC.