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Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

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Published on: November 5, 2011

Stem cell transplantation in India.

¹Hematology Department, The Christian Medical College, Vellore, India. mammen@cmcvellore.ac.in

Bone Marrow Transplantation

|September 25, 2008

Summary

This summary is machine-generated.

Bone marrow transplantation (BMT) activity in India is growing, with 1540 transplants performed by 2005. Thalassemia is a major indication, and costs are significantly lower than in Western countries.

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Area of Science:

Hematology
Transplant Medicine
Public Health

Background:

Bone marrow transplantation (BMT) is a critical treatment for various hematological disorders.
India, with a population exceeding one billion, faces a significant burden of diseases treatable by BMT, notably thalassemia.
The Christian Medical College, Vellore, has a long-standing BMT program contributing to national activity.

Purpose of the Study:

To provide an overview of bone marrow transplantation (BMT) activity in India.
To detail the BMT program at the Christian Medical College, Vellore.
To highlight the prevalence of thalassemia as a key indication for BMT in India.

Main Methods:

Data collection from six transplant centers across India in September 2005.
Review of patient records from the Christian Medical College, Vellore, spanning October 1986 to December 2006.
Analysis of transplant indications, patient numbers, and cost of procedures.

Main Results:

A total of 1540 BMTs were performed across six centers in India by September 2005.
The Christian Medical College, Vellore, performed 626 BMTs in 595 patients between October 1986 and December 2006.
Thalassemia represented one-third of all transplants, with over 20 million carriers and 10,000 new cases of thalassemia major annually in India.

Conclusions:

India has a substantial and growing BMT program, particularly for thalassemia.
The average cost of allogeneic BMT in India ($15,000-20,000) is substantially lower than in Western countries.
There is a pressing need for expanded BMT facilities and trained personnel in India to meet the growing demand, supported by economic improvements enabling more patients to access treatment.