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Clinical and laboratory profile of anti-M
1Transfusion Medicine, Tata Medical Center , 14 Middle Arterial Road (EW), Rajarhat, New Town, Kolkata 700160 , India.
Abstract:
Anti-M is a frequently detected naturally occurring antibody that has been reported in various clinical settings and also in voluntary donors. We describe here the clinical and laboratory findings of 11 cases with anti-M detected at our center. This report is a retrospective study in which we reviewed our immunohematology laboratory records for cases involving anti-M. Both donor and patient data from a 28-month period (September 2014 to December 2016) were reviewed. During this period, 11 examples of anti-M were detected (8 patients, 1 voluntary whole blood donor, and 1 hematopoietic stem cell donor. Anti-M was also detected in one external quality assessment scheme sample received during this period. In conclusion, anti-M can be detected in various clinical settings. This antibody can be clinically significant; in the laboratory, it can present as a serologic problem such as an ABO group discrepancy or an incompatible crossmatch. After detection, management and course of action is determined by both the antibody characteristics and the clinical setting.
Abstract:
Anti-M is a frequently detected naturally occurring antibody that has been reported in various clinical settings and also in voluntary donors. We describe here the clinical and laboratory findings of 11 cases with anti-M detected at our center. This report is a retrospective study in which we reviewed our immunohematology laboratory records for cases involving anti-M. Both donor and patient data from a 28-month period (September 2014 to December 2016) were reviewed. During this period, 11 examples of anti-M were detected (8 patients, 1 voluntary whole blood donor, and 1 hematopoietic stem cell donor. Anti-M was also detected in one external quality assessment scheme sample received during this period. In conclusion, anti-M can be detected in various clinical settings. This antibody can be clinically significant; in the laboratory, it can present as a serologic problem such as an ABO group discrepancy or an incompatible crossmatch. After detection, management and course of action is determined by both the antibody characteristics and the clinical setting.
Insights
Anti-M antibodies are naturally occurring and can be detected in donors and patients. These antibodies may cause serologic issues like ABO discrepancies or incompatible crossmatches, requiring careful management.
Area of Science:
- Immunohematology
- Transfusion Medicine
- Serology
Background:
- Anti-M is a common naturally occurring antibody.
- It is detected in both voluntary blood donors and patients.
- Clinical significance and laboratory challenges associated with Anti-M are not fully understood.
Purpose of the Study:
- To describe the clinical and laboratory findings of 11 cases with Anti-M.
- To analyze the incidence and presentation of Anti-M in a specific center.
- To highlight the potential clinical significance and serologic problems caused by Anti-M.
Main Methods:
- Retrospective review of immunohematology laboratory records.
- Analysis of donor and patient data over a 28-month period (September 2014 to December 2016).
- Identification of cases with detected Anti-M.
Main Results:
- Eleven instances of Anti-M detection were identified.
- These included 8 patients, 1 voluntary whole blood donor, and 1 hematopoietic stem cell donor.
- Anti-M was also found in an external quality assessment sample.
Conclusions:
- Anti-M can be detected in diverse clinical settings.
- This antibody can pose significant clinical challenges, including ABO discrepancies and crossmatch incompatibilities.
- Management strategies depend on antibody characteristics and the clinical context.
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