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Updated: Jul 2, 2026
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An Intra-Tissue Radiometry Microprobe for Measuring Radiance In Situ in Living Tissue
Published on: June 2, 2023
Measuring tissue heat penetration by scattered light measurements
M Ben-David1, R Cantor, N Balbul
1Department of Biomedical Engineering, Tel-Aviv University, Tel-Aviv, Israel.
Lasers in Surgery and Medicine
|August 30, 2008
Summary
Monitoring tissue changes during laser procedures is crucial for preventing damage. This study proposes an optical method using scattered light patterns to control laser thermal interactions in real-time.
Area of Science:
- Biomedical Optics
- Laser-Tissue Interaction
- Medical Imaging
Background:
- Monitoring tissue during laser procedures like thermotherapy is vital to prevent collateral damage.
- Real-time assessment of in vivo tissue morphological changes is needed.
Purpose of the Study:
- To propose an optical system and method for real-time in vivo assessment of tissue morphological changes.
- To develop a method for controlling laser thermal interactions.
Main Methods:
- Ex vivo chicken breast samples were subjected to CO(2) laser irradiation.
- Optical properties, heat penetration, and scattered light were measured using an integrating sphere.
- Results were compared with Monte Carlo simulations.
Main Results:
- Laser thermal interaction induced structural changes, increasing tissue scattering properties.
- A correlation was established between structural changes and scattered light patterns.
- A method for controlling thermal interaction based on scattered light was proposed.
Conclusions:
- Real-time in vivo control of laser-tissue thermal interaction is feasible.
- Changes in scattered light patterns can be utilized for effective control.
