Fat-water separated delayed hyperenhanced myocardial infarct imaging

Fat deposition associated with myocardial infarction (MI) has been reported as a commonly occurring phenomenon. Magnetic resonance imaging (MRI) has the ability to efficiently detect MI using T(1)-sensitive contrast-enhanced sequences and fat via its resonant frequency shift. In this work, the feasibility of fat-water separation applied to the conventional delayed hyperenhanced (DHE) MI imaging technique is demonstrated. A three-point Dixon acquisition and reconstruction was combined with an inversion recovery gradient-echo pulse sequence. This allowed fat-water separation along with T(1) sensitive imaging after injection of a gadolinium contrast agent. The technique is demonstrated in phantom experiments and three subjects with chronic MI. Areas of infarction were well defined as conventional hyperenhancement in water images. In two cases, fatty deposition was detected in fat images and confirmed by precontrast opposed-phase imaging.