Related Experiment Video
Updated: Jul 2, 2026

A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies
Published on: November 7, 2015
[A relationship of congenital brain malformations and tumor growth]
Abstract:
The peritumor-like areas of 12 cerebral hemispheric tumors were examined. Histological study revealed vascular malformations and/or congenital tissue dysplasias in all cases: cortical disorganization, neuronal heterotopy into the white matter, neural location in the molecular cortical layer, and persistence of a subpial granular cell layer. Immunohistochemical study using Ki-67 antibodies in the peritumor-like tissue dysplasias revealed proliferative activity in a number of cases. The associations of the origin of brain tumors and congenital malformations are discussed.
Related Concept Videos
Teratogenicity
Neurulation
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Brain Abscess l: Introduction
