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Diclofenac hepatitis.

R W Sallie1, T McKenzie, W D Reed

  • 1Department of Medicine, University of Western Australia, Perth.

Australian and New Zealand Journal of Medicine
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

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Diclofenac can cause liver injury (hepatitis) in some individuals, typically appearing weeks after use. Most patients recover fully after stopping the drug, though some may require treatment.

Area of Science:

  • Hepatology
  • Clinical Pharmacology
  • Drug-Induced Liver Injury

Background:

  • Diclofenac is a widely used nonsteroidal anti-inflammatory drug (NSAID).
  • Drug-induced liver injury (DILI) is a significant concern with NSAID use.
  • Understanding the spectrum and incidence of diclofenac-associated hepatitis is crucial.

Observation:

  • Five cases of biopsy-proven hepatitis occurred 6-20 weeks post-diclofenac.
  • One patient had prior jaundice with ibuprofen; another developed chronic active hepatitis requiring corticosteroids.
  • Three patients developed transient autoantibodies, suggesting immune involvement.

Findings:

  • All patients recovered without long-term sequelae, except for one with chronic active hepatitis.
  • Symptom resolution took 3-12 weeks; liver function normalized in 7-16 weeks.

Related Experiment Videos

  • The incidence of severe hepatic dysfunction is estimated at 1 in 50,000-100,000 prescriptions.

    • Implications:

    • Immune mechanisms may play a role in diclofenac-induced liver injury.
    • While rare, severe hepatitis necessitates prompt drug cessation.
    • This study highlights the importance of monitoring liver function in patients using diclofenac.