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Updated: Jul 2, 2026
08:49
Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Tailoring T-cell receptor signals by proximal negative feedback mechanisms
Oreste Acuto1, Vincenzo Di Bartolo, Frédérique Michel
1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. oreste.acuto@path.ox.ac.uk
Nature Reviews. Immunology
|August 30, 2008
Summary
Novel negative feedback mechanisms rapidly activated by T-cell receptor (TCR) engagement regulate immune responses. These findings are crucial for understanding T-cell signaling and ligand discrimination in immunity and tolerance.
Area of Science:
- Immunology
- Cellular Signaling
- Molecular Biology
Background:
- T-cell receptor (TCR) signaling dictates T-cell responses, distinguishing self from non-self for immunity or tolerance.
- This discrimination is challenging due to the fine balance required and complex genetic programs involved.
Purpose of the Study:
- To investigate novel negative feedback mechanisms in TCR signaling.
- To understand the role of these mechanisms in regulating T-cell activation and signal propagation.
Main Methods:
- Utilized in vitro and in vivo experimental approaches.
- Focused on analyzing the impact of TCR engagement on signaling pathways.
Main Results:
- Identified novel negative feedback mechanisms rapidly induced upon TCR engagement.
- Demonstrated the critical role of these mechanisms in regulating signal triggering and propagation.
- Evidence suggests involvement in TCR ligand discrimination and signal output control.
Conclusions:
- Rapidly induced negative feedback mechanisms are key regulators of TCR signaling.
- These mechanisms are essential for accurate T-cell responses, influencing both ligand discrimination and signal output.
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