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Related Experiment Video

Updated: Jul 2, 2026

Assessment of Chemical Toxicity in Adult Drosophila Melanogaster

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Published on: March 24, 2023

Domoic acid toxicologic pathology: a review.

Olga M Pulido¹

¹Bureau of Chemical Safety, Food Directorate, Health Products and Food Branch, Health Canada, 251 Sir Frederick Banting Dr., 2202D2, Tunney's Pasture, Ottawa, ON, Canada. Olga_Pulido@hc-sc.gc.ca

|August 30, 2008

Summary

Domoic acid causes Amnesic Shellfish Poisoning (ASP), leading to memory loss. This review covers domoic acid pathology, its mechanisms, and food safety concerns for humans and wildlife.

Keywords:

Amnesic Shellfish Poisoning Domoic Acid Excitotoxicity Food Safety Glutamate Receptors Neuropathology Neurotoxicology Toxicologic Pathology

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Toxicity Screens in Human Retinal Organoids for Pharmaceutical Discovery

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Published on: March 4, 2021

Area of Science:

Marine toxicology
Neuroscience
Food safety

Background:

Domoic acid (DA) is a marine toxin responsible for Amnesic Shellfish Poisoning (ASP) outbreaks.
First identified in a 1987 Canadian mussel poisoning incident, ASP is characterized by severe memory impairment.
DA is produced by marine algae and diatoms, posing a global risk to human and wildlife health.

Purpose of the Study:

To provide a comprehensive review of ASP and domoic acid (DA) induced pathology.
To discuss the mechanisms of cell/tissue injury in DA-induced brain pathology.
To address food safety and human health considerations related to DA exposure.

Main Methods:

Literature review of ASP and domoic acid (DA) research.
Analysis of clinical symptoms and pathological findings associated with DA intoxication.
Discussion of proposed neurotoxic mechanisms, including glutamate receptor involvement.

Main Results:

Domoic acid (DA) causes significant neurotoxicity, primarily affecting memory.
Ultrastructural changes are observed following subchronic oral DA exposure.
Glutamate receptors are implicated in DA's neurotoxic effects, with potential targets beyond the central nervous system.

Conclusions:

Domoic acid (DA) remains a significant global health concern for both humans and wildlife.
Understanding DA's mechanisms of toxicity is crucial for risk assessment and management.
Effective monitoring programs are essential for preventing future ASP incidents and ensuring food safety.