Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Compartment Models: Single-Compartment Model01:14

Compartment Models: Single-Compartment Model

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this...
Compartment Models: Two-Compartment Model01:20

Compartment Models: Two-Compartment Model

The two-compartment model divides the body into central and peripheral compartments to account for varying blood perfusion rates among organs and tissues, affecting drug distribution. The central compartment includes blood and highly perfused tissues with rapid drug distribution, while the peripheral compartment contains tissues with slower drug distribution. After a single IV bolus dose, the drug concentration is high in plasma and low in tissues. The drug distribution between compartments...
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
Mechanistic Models: Overview of Compartment Models01:21

Mechanistic Models: Overview of Compartment Models

Mechanistic models, a category encompassing both physiological and compartmental modeling, differ from empirical models' approaches to incorporating known factors about the systems being modeled. Empirical models describe data with minimal assumptions, while mechanistic models aim to provide a robust description of available data by specifying assumptions and integrating known factors about the system. Compartmental analysis is a key example of a mechanistic model in pharmacokinetics and...
Clearance Models: Compartment Models01:25

Clearance Models: Compartment Models

Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume of...
Typical Model Studies01:30

Typical Model Studies

Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Terrace simultaneous chaining paradigm.

Behavioural processes·2010
Same author

Decision-making models of remember-know judgments: comment on Rotello, Macmillan, and Reeder (2004).

Psychological review·2006
Same author

The recall of missing items.

Memory & cognition·2005
Same author

Storage and retrieval of serial-order information.

Memory (Hove, England)·2005
Same author

The mirror effect and the spacing effect.

Psychonomic bulletin & review·2003
Same author

Item and associative recognition with precuing and postcuing.

Journal of experimental psychology. Learning, memory, and cognition·2003

Related Experiment Video

Updated: Jul 2, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Issues with the SIMPLE model: comment on Brown, Neath, and Chater (2007).

Bennet Murdock1

  • 1Department of Psychology, University of Toronto, Toronto, Ontario, Canada. murdock@psych.utoronto.ca

Psychological Review
|August 30, 2008
PubMed
Summary

The SIMPLE model explains free recall but struggles with serial recall challenges like similarity and presentation rate effects. Further research is needed to address these limitations in short-term memory models.

More Related Videos

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

Related Experiment Videos

Last Updated: Jul 2, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome
06:51

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction
11:07

Engineering and Characterization of an Optogenetic Model of the Human Neuromuscular Junction

Published on: April 14, 2022

Area of Science:

  • Cognitive Psychology
  • Memory Research

Background:

  • The 2-store buffer model is a cornerstone of short-term memory research.
  • SIMPLE (G. D. A. Brown, I. Neath, & N. Chater, 2007) is a theoretical framework attempting to unify free and serial recall.
  • Classic short-term memory research includes similarity effects and presentation-rate effects.

Purpose of the Study:

  • To evaluate the SIMPLE model's ability to explain data from both serial and free recall tasks.
  • To identify limitations of the SIMPLE model in addressing key phenomena in short-term memory.

Main Methods:

  • Analysis of existing theoretical frameworks for short-term memory.
  • Comparison of SIMPLE model's explanatory power against established findings in free and serial recall.

Main Results:

  • SIMPLE can fit free-recall serial-position curves but does not account for similarity effects in free or serial recall.
  • Presentation-rate effects are not adequately addressed by SIMPLE, as they differ between free and serial recall.
  • The model overlooks recall order effects and interresponse times in free recall.

Conclusions:

  • The SIMPLE model, while explaining some aspects of free recall, has significant limitations.
  • Further theoretical development is required to encompass a broader range of short-term memory phenomena, including similarity and presentation-rate effects.
  • Addressing recall order and interresponse times is crucial for a comprehensive short-term memory model.