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Related Experiment Videos

Human preimplantation embryo cryopreservation: selected aspects.

E F Fugger1, M Bustillo, A D Dorfmann

  • 1Genetics & IVF Institute, Fairfax, VA 22031.

Human Reproduction (Oxford, England)
|January 1, 1991
PubMed
Summary

Cryopreserving human embryos, including zygotes and cleaved embryos, shows similar survival rates and enhances overall pregnancy success in in-vitro fertilization (IVF) programs. This reliable procedure improves cumulative pregnancy achievement.

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Area of Science:

  • Reproductive Medicine
  • Embryology
  • In-Vitro Fertilization (IVF)

Background:

  • Cryopreservation of human preimplantation embryos is a key technique in assisted reproductive technology.
  • Optimizing embryo survival and pregnancy rates post-thaw is crucial for IVF success.

Purpose of the Study:

  • To evaluate the outcomes of cryopreserving human zygotes and cleaved embryos.
  • To compare pregnancy rates and implantation success between frozen-thawed and fresh embryos.
  • To assess factors influencing pregnancy rates in frozen-thawed embryo transfer cycles.

Main Methods:

  • Cryopreservation of human zygotes and 2-4 cell stage cleaved embryos.
  • Comparison of post-thaw survival rates between zygotes and cleaved embryos.
  • Analysis of pregnancy and implantation rates based on embryo status (fresh vs. frozen-thawed), number of embryos transferred, and patient history.

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Main Results:

  • Similar post-thaw survival rates for cryopreserved zygotes (74.8%) and cleaved embryos (70.9%).
  • Increased pregnancy rates with the transfer of three or more embryos, for both fresh and frozen-thawed embryos.
  • Higher multiple implantation rates for frozen-thawed embryos (25%) compared to fresh embryos (6.4%) when two embryos were transferred.
  • Cumulative pregnancy rates were significantly higher in patients with cryopreserved embryos (37.1%) compared to those without (23.5%).

Conclusions:

  • Cryopreservation of human preimplantation embryos is a reliable and effective therapeutic procedure.
  • Embryo cryopreservation significantly enhances the cumulative achievement of pregnancy in IVF programs.
  • Transferring multiple embryos (3+) improves pregnancy rates for both fresh and frozen-thawed cycles.