[Anatomohistological characteristics of Meckel's diverticulum in human fetuses]

Snezana Pavlović1, Dejan Zdravković, Natalija Stefanović

  • 1Medicinski fakultet, Institut za anatomiju, Nis, Srbija. sneska@medfak.ni.ac.yu

Vojnosanitetski Pregled
|August 30, 2008
PubMed
Abstract

Insights

Meckel's diverticulum (MD) was found in 3.3% of fetuses, with a 4% incidence among vitelline duct anomalies. This common small intestine anomaly occurred more frequently in males and its location correlated with fetal age.

Area of Science:

  • Developmental biology
  • Embryology
  • Gastrointestinal pathology

Context:

  • Meckel's diverticulum (MD) is the most common congenital anomaly of the small intestine.
  • It arises from the incomplete obliteration of the omphalomesenteric (vitelline) duct by the 9th week of gestation.
  • While often asymptomatic, MD can lead to complications like obstruction, hemorrhage, or rupture.

Purpose:

  • To determine the incidence of Meckel's diverticulum in human fetuses.
  • To analyze the location and characteristics of MD in a fetal cohort.
  • To correlate MD occurrence with fetal development and sex.

Summary:

  • This study investigated 150 human fetuses using microdissection.
  • Meckel's diverticulum was identified in 3.3% of fetuses (5 out of 150).
  • The incidence of MD among vitelline duct anomalies was 4%, with a higher prevalence in males and location correlating with fetal age.

Impact:

  • Provides crucial incidence data for fetal Meckel's diverticulum.
  • Contributes to understanding the developmental origins of gastrointestinal anomalies.
  • Informs prenatal diagnostics and pediatric surgical planning for Meckel's diverticulum.

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