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[Anatomohistological characteristics of Meckel's diverticulum in human fetuses]
Snezana Pavlović1, Dejan Zdravković, Natalija Stefanović
1Medicinski fakultet, Institut za anatomiju, Nis, Srbija. sneska@medfak.ni.ac.yu
Background/Aim:
Meckel's diverticulum (MD) is the most frequent anomaly of the small intestine. It appears after incomplete obliteration of the omphalomesenteric or viteline duct which normaly obliterates and disappears by the 9th week of gestation. The majority of MD do not give rise to any clinical symptoms and are encounted either incidentally, at examination or intervention, or due to complications which may occur (obstruction, hemorrhagy, rupture), and are described in many clinical reports. The aim of the study was to find out the incidence of MD in fetuses when the development of the alimentary tract is already finished.
Methods:
The investigation was performed on 150 human fetuses of different sex and gastational age, using microdissection method. The cases with MD were photographed, described, their positions and dimensions were registered. The samples of MD taken for histological investigation were dyed with hematoksilin eosin method.
Results:
Meckel's diverticulum was found in five fatuses (three male and two female); in one case the fibrous band was found. All of them were located on animesenteric margine of the small intestine at the average distance of 92.5 mm from the ileocecal junction. They were of different shape and dimensions, but of the normal constitution of the small intestine.
Conclusion:
The incidence of MD was 3.3%, and 4% of all the anomalies of the intestines connected to the disappearance of the viteline duct. It was more frequent in the male, located on antimesenteric margine of the small intestine, at the destination which highly correlated to the age of the fetus. Meckel's diverticule were of different shapes and dimensions but of the typical constitution of the small intestine.
Insights
Meckel's diverticulum (MD) was found in 3.3% of fetuses, with a 4% incidence among vitelline duct anomalies. This common small intestine anomaly occurred more frequently in males and its location correlated with fetal age.
Area of Science:
- Developmental biology
- Embryology
- Gastrointestinal pathology
Context:
- Meckel's diverticulum (MD) is the most common congenital anomaly of the small intestine.
- It arises from the incomplete obliteration of the omphalomesenteric (vitelline) duct by the 9th week of gestation.
- While often asymptomatic, MD can lead to complications like obstruction, hemorrhage, or rupture.
Purpose:
- To determine the incidence of Meckel's diverticulum in human fetuses.
- To analyze the location and characteristics of MD in a fetal cohort.
- To correlate MD occurrence with fetal development and sex.
Summary:
- This study investigated 150 human fetuses using microdissection.
- Meckel's diverticulum was identified in 3.3% of fetuses (5 out of 150).
- The incidence of MD among vitelline duct anomalies was 4%, with a higher prevalence in males and location correlating with fetal age.
Impact:
- Provides crucial incidence data for fetal Meckel's diverticulum.
- Contributes to understanding the developmental origins of gastrointestinal anomalies.
- Informs prenatal diagnostics and pediatric surgical planning for Meckel's diverticulum.
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