Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mean time parameters for generalized physiological flow models (semihomogeneous linear systems).

D Verotta1, L B Sheiner, S L Beal

  • 1Department of Laboratory Medicine, School of Medicine, University of California San Francisco 94143-0626.

Journal of Pharmacokinetics and Biopharmaceutics
|June 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacodynamic measurements of methyl nicotinate percutaneous absorption.

Pharmaceutical research·2013
Same author

Every 36-h gentamicin dosing in neonates with hypoxic-ischemic encephalopathy receiving hypothermia.

Journal of perinatology : official journal of the California Perinatal Association·2013
Same author

Population analyses of atorvastatin clearance in patients living in the community and in nursing homes.

Clinical pharmacology and therapeutics·2009
Same author

A new Bayesian method to forecast and fine tune individual hemodialysis dose.

Hemodialysis international. International Symposium on Home Hemodialysis·2009
Same author

Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects.

British journal of clinical pharmacology·2005
Same author

Ways to fit a PK model with some data below the quantification limit.

Journal of pharmacokinetics and pharmacodynamics·2002
Same journal

Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics.

Journal of pharmacokinetics and biopharmaceutics·2010
Same journal

Applications of a recirculatory stochastic pharmacokinetic model: limitations of compartmental models.

Journal of pharmacokinetics and biopharmaceutics·2010
Same journal

Effect of plasma protein and tissue binding on the time course of drug concentration in plasma.

Journal of pharmacokinetics and biopharmaceutics·2010
Same journal

Pharmacokinetics of methotrexate in solid tumors.

Journal of pharmacokinetics and biopharmaceutics·2010
Same journal

Single- and multiple-dose kinetics of oral lorazepam in humans: the predictability of accumulation.

Journal of pharmacokinetics and biopharmaceutics·2010
Same journal

Comparison of the in vitro and in vivo release of digoxin from four different soft gelatin capsule formulations.

Journal of pharmacokinetics and biopharmaceutics·2010
See all related articles

This study provides methods to calculate recirculation mean time parameters for disposition kinetics in linear systems. These methods allow for estimation of blood flow and disposition functions, even with complex, non-exponential models.

Area of Science:

  • Pharmacokinetics and Systems Pharmacology
  • Mathematical Modeling in Biology
  • Physiological Flow Systems

Background:

  • Traditional pharmacokinetic models often assume simple, monoexponential disposition functions.
  • Physiological flow models typically require known parametric functions for each compartment.
  • Estimating disposition kinetics in complex systems with recirculation is challenging.

Purpose of the Study:

  • To derive expressions for recirculation mean time parameters in semihomogeneous stationary linear systems.
  • To generalize physiological flow models by allowing arbitrary single-pass disposition functions.
  • To enable estimation of tissue blood flow and disposition functions from experimental data.

Main Methods:

  • Developed mathematical expressions for recirculation mean time parameters.

Related Experiment Videos

  • Utilized observations of arterial blood concentrations and tissue amounts.
  • Applied assumptions regarding constant and known fractions of blood flow and elimination between tissues.
  • Estimated tissue input, total blood flow, and single-pass disposition functions.

    • Main Results:

    • Provided a method to compute recirculation mean time parameters.
    • Demonstrated the estimation of blood flow and disposition functions for systems with arbitrary single-pass functions.
    • Successfully applied the method to real thiopental data, validating the approach.

    Conclusions:

    • The derived expressions allow for accurate calculation of recirculation mean time parameters.
    • The methodology extends the applicability of pharmacokinetic modeling to more complex physiological systems.
    • This approach offers a robust framework for analyzing disposition kinetics in the presence of recirculation.