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Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics
1Department of Pharmacy, College of Pharmacy, University of Illinois at the Medical Center, Chicago, Illinois 60612, USA.
Abstract:
Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed.
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