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Pharmacokinetics of methotrexate in solid tumors

R K Jain1, J Wei, P M Gullino

  • 1Department of Chemical Engineering, University of Delaware, Newark, Delaware 19711, USA.

Journal of Pharmacokinetics and Biopharmaceutics
|March 12, 2010
PubMed
Summary

Methotrexate (MTX) transport into tumors differs based on tumor type and drug dosage. Mathematical modeling revealed flow-limited uptake in hepatoma 5123 and tissue-limited uptake in Walker 256 carcinoma.

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