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Ole Isacson: Development of New Therapies for Parkinson's Disease

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Published on: April 29, 2007

At what age do biomedical scientists do their best work?

Matthew E Falagas¹, Vrettos Ierodiakonou, Vangelis G Alexiou

¹Alfa Institute of Biomedical Sciences, 9 Neapoleos St., 151 23 Marousi, Athens, Greece. m.falagas@aibs.gr

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology

|August 30, 2008

Summary

Investigator age and scientific output show an inverted U-shape curve. Peak research productivity occurs in early career stages, with a notable decline after age 40, though older scientists still contribute significantly.

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Area of Science:

Biomedical research
Scientometrics
Career development

Background:

Scientist performance is influenced by age-related factors.
Understanding the relationship between investigator age and research quality is crucial.

Purpose of the Study:

To investigate the association between investigator age and high-quality scientific productivity.
To determine if research output peaks at specific career stages.

Main Methods:

Randomly selected 300 highly cited scientists across six biomedical fields.
Analyzed the top 5 highly cited articles per scientist, focusing on first-author publications.
Plotted article publication age distribution adjusted for scientist-years at risk.

Main Results:

High-quality research productivity peaked between ages 31-35.
Productivity showed a gradual decrease after age 35 and significant decline after 40.
Approximately 20% of highly cited articles were produced by scientists over 50.

Conclusions:

Biomedical research productivity follows an inverted U-shaped curve concerning investigator age.
Significant declines in high-quality output are observed from age 40 onwards.
Older scientists remain valuable contributors to scientific advancement.